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BIJSLUITER: INFORMATIE VOOR DE GEBRUIKER Bicalutamide ... BIJSLUITER: INFORMATIE VOOR DE GEBRUIKER Bicalutamide ...
Bicalutamide EG 150 mg filmomhulde tabletten bicalutamide. Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat belangrijke ...

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As such, concomitant use of terfenadine, astemizole and cisapride is contraindicated (see section 4. The pharmacokinetics of the (r)-enantiomer are unaffected by age, renal impairment or mild to moderate hepatic impairment. No recovery was observed at 24 weeks after the completion of dosing in a 12-month rat study (at doses of approximately 0.

Although the effect of bicalutamide on sperm morphology has not been evaluated and no such changes have been reported for patients who received casodex, patients andor their partners should follow adequate contraception during and for 130 days after casodex therapy. It is therefore recommended that if casodex 150 mg is administered in patients who are concomitantly receiving coumarin anticoagulants, ptinr should be closely monitored and adjustments of anticoagulant dose considered (see sections 4. For drugs with a narrow therapeutic index such an increase could be of relevance.

Casodex is unlikely to impair the ability of patients to drive or operate machinery. Casodex 150 mg is indicated either alone or as adjuvant to radical prostatectomy or radiotherapy in patients with locally advanced prostate cancer at high risk for disease progression (see section 5. Casodex 150 mg is also indicated for the management of patients with locally advanced, non-metastatic prostate cancer for whom surgical castration or other medical intervention is not considered appropriate or acceptable.

Casodex 150 mg must not be given to any patient who has shown a hypersensitivity reaction to the active substance or to any of the excipients listed in section 6. Adult males including the elderly the dosage is one 150 mg tablet to be taken orally once a day. This is below that required to induce changes in offspring of laboratory animals.

Interaction with other medicinal products and other forms of interaction studies have shown that r-bicalutamide is an inhibitor of cyp 3a4, with lesser inhibitory effects on cyp 2c9, 2c19 and 2d6 activity. Pvcaluminium foil blister pack comprising strips of 5, 10 and 14 tablets to give pack sizes of 10, 20, 30, 40, 50, 80, 90, 100, 200 or 14, 28, 56, 84, 140 and 280 tablets. Potentiation of coumarin anticoagulant effects have been reported in patients receiving concomitant casodex therapy, which may result in increased prothrombin time (pt) and international normalised ratio (inr).

The (s)-enantiomer is rapidly cleared relative to (r)-enantiomer, the latter having a plasma elimination half-life of about 1 week. Dosage reduction may be required for these drugs particularly if there is evidence of enhanced or adverse drug effect. . In rare cases, photosensitivity reactions have been reported for patients taking casodex 150 mg. Casodex 150 mg should be taken continuously for at least 2 years or until disease progression.


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CASODEX150, 150 mg, filmomhulde tabletten bicalutamide . Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat belangrijke.

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Bijsluiter: informatie voor de patiënt Bicalutamide Sandoz 150 mg ...
Bicalutamide Sandoz 150 mg filmomhulde tabletten. Bicalutamide. Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat.
Casodex 150 Mg Bijsluiter Viagra Sale Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat. Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat belangrijke. Steady state plasma concentrations of the (r)-enantiomer, There is evidence that for subjects with severe hepatic impairment, the (r)-enantiomer is more slowly eliminated from plasma. Dosage reduction may be required for these drugs particularly if there is evidence of enhanced or adverse drug effect. For patients who have an objective progression of disease together with elevated psa, cessation of casodex therapy should be considered. Casodex with compounds such as ciclosporin and calcium channel blockers. Reversible impairment of male fertility has been observed in animal studies (see section 5. In patients with a history of or risk factors for qt prolongation and in patients receiving concomitant medicinal products that might prolong the qt interval (see section 4. Increased accumulation may occur in patients with moderate to severe hepatic impairment (see section 4. For ciclosporin, it is recommended that plasma concentrations and clinical condition are closely monitored following initiation or cessation of casodex therapy. The majority of changes are expected to occur within the first 6 months of casodex therapy.
  • 1. Wat is Biluron 150 mg en waarvoor wordt dit middel ... - Cbg Meb


    Any unused medicinal product or waste material should be disposed of in accordance with local requirements. By continuing to browse the site you are agreeing to our policy on the use of cookies. As such, concomitant use of terfenadine, astemizole and cisapride is contraindicated (see section 4. Reversible impairment of male fertility has been observed in animal studies (see section 5. A period of subfertility or infertility should be assumed in man.

    Although clinical studies using antipyrine as a marker of cytochrome p450 (cyp) activity showed no evidence of a drug interaction potential with casodex, mean midazolam exposure (auc) was increased by up to 80 after co-administration of casodex for 28 days. Severe hepatic changes and hepatic failure have been observed rarely with casodex 150 mg, and fatal outcomes have been reported (see section 4. It is therefore recommended that if casodex 150 mg is administered in patients who are concomitantly receiving coumarin anticoagulants, ptinr should be closely monitored and adjustments of anticoagulant dose considered (see sections 4. In patients with a history of or risk factors for qt prolongation and in patients receiving concomitant medicinal products that might prolong the qt interval (see section 4. Pvcaluminium foil blister pack comprising strips of 5, 10 and 14 tablets to give pack sizes of 10, 20, 30, 40, 50, 80, 90, 100, 200 or 14, 28, 56, 84, 140 and 280 tablets.

    However, it should be noted that occasionally somnolence may occur. In cases where the photosensitivity reaction is more persistent andor severe, an appropriate symptomatic treatment should be initiated. Casodex with compounds such as ciclosporin and calcium channel blockers. Renal impairment no dosage adjustment is necessary for patients with renal impairment. Potentiation of coumarin anticoagulant effects have been reported in patients receiving concomitant casodex therapy, which may result in increased prothrombin time (pt) and international normalised ratio (inr). Casodex 150 mg must not be given to any patient who has shown a hypersensitivity reaction to the active substance or to any of the excipients listed in section 6. Following 12 months of repeated dosing in dogs (at doses of approximately 3 times human therapeutic concentrations at the recommended human dose of 150 mg), the incidence of testicular atrophy was the same in dosed and control dogs after a 6-month recovery period. Co-administration of terfenadine, astemizole or cisapride with casodex is contraindicated (see section 4. For patients who have an objective progression of disease together with elevated psa, cessation of casodex therapy should be considered. Patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

    Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat innemen want er staat ... Biluron 150 mg is een geneesmiddel met de actieve stof bicalutamide.

    Casodex 150 mg Film-coated Tablets. - Summary of Product ...

    Casodex 150 mg is indicated either alone or as adjuvant to radical prostatectomy or radiotherapy in patients with locally advanced prostate cancer at high risk ...
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    Casodex 150 mg therapy should be discontinued if changes are severe. Close monitoring of ptinr is advised and anticoagulant dose adjustment should be considered (see sections 4. The majority of changes are expected to occur within the first 6 months of casodex therapy. Casodex with compounds such as ciclosporin and calcium channel blockers. As such, concomitant use of terfenadine, astemizole and cisapride is contraindicated (see section 4.

    In a clinical study, the mean concentration of r-bicalutamide in semen of men receiving casodex 150 mg was 4. Caution should be exercised when prescribing casodex with other drugs which may inhibit drug oxidation e...

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    Bicalutamide is a potent antiandrogen and a mixed function oxidase enzyme inducer in animals. The majority of changes are expected to occur within the first 6 months of casodex therapy. Casodex 150 mg should be taken continuously for at least 2 years or until disease progression. When suggestions are available use up and down arrows to review and enter to select. The amount of bicalutamide potentially delivered to a female partner during intercourse is low and equates to approximately 0.

    Patients should be advised to avoid direct exposure to excessive sunlight or uv-light while on casodex 150 mg and the use of sunscreens may be considered...

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    Periodic liver function testing should be considered due to the possibility of hepatic changes. Casodex 150 mg is also indicated for the management of patients with locally advanced, non-metastatic prostate cancer for whom surgical castration or other medical intervention is not considered appropriate or acceptable. Caution should be exercised when prescribing casodex with other drugs which may inhibit drug oxidation e. Patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Bicalutamide has been shown to inhibit cytochrome p450 (cyp3a4), as such, caution should be exercised when co-administered with drugs metabolised predominantly by cyp 3a4 (see sections 4...